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HomeKey Reactions

Key Reactions

We have done most kinds of reactions successfully, including traditional and new-appearing reactions. The following examples are some of which we are quite familiar with or have been done in commercial lot frequently.

1
Debenzylation  
2
Heterocyclics Synthesis
3
Reduction Reactions  
4
Oxidation Reactions
5
Suzuki Coupling  
6
Heck-Fujiwara Coupling
7
Grignard Reactions  
8
Dies-Alder Reactions
9
Esterification and Ester Change Reaction  
10
Chiral Reactions

 

1. Debenzylation
Debenzylation
 
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2. Heterocyclics Synthesis
2.1. Fischer Indole Synthesis
Fisher Indole Synthesis
2.2. Imidazole Synthesis
Imidazole synthesis
2.3. Indazole synthesis
Indazole synthesis
2.4. Quinoline synthesis
Quinoline synthesis
2.5. Thiazole synthesis
Thiazole synthesis
2.6. Oxazole synthesis
Oxazole synthesis
 
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3. Reduction Reactions
3.1. Reduction with Lithium Aluminum Hydride
3.2. Reduction with Borohydride
3.2.1 Sodium Borohydride
3.2.2 Zinc Borohydride
3.2.3 Sodium Cyanoborohydride
3.3 Reduction with Diisobutylaluminum Hydride
3.4 Catalytic Hydrogenation
3.5 Reduction with Hydrazine (Wolff-Kishner)
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4. Oxidation Reactions
4.1 Oxidation with Chromium (VI)
4.1.1 Collins oxidation
4.1.2 PCC reagent
4.2 Dimethyl Sulfoxide Oxidations
4.2.1 Dimethyl Sulfoxide - Acetic Anhydride reagent
4.2.2 Swern Oxidation
4.3 Oxidation with Manganese Dioxide
4.4 Dess-Martin Periodinane Oxidation
4.5 mCBPA reagent
4.6 Oxidation with Permanganate
 
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5. Suzuki Coupling
 
6. Heck-Fujiwara Coupling
 
7. Grignard Reactions
 
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8. Dies-Alder Reactions
 
9. Esterification and Ester Change Reaction
9.1 Esterification
 
9.2 Ester Change reaction
 
10. Chiral Reactions
  • Kinetic resolution with D-TA and DDA
  • Chiral ligand-supported hydrogenation
  • Auxiliary-assistant synthesis
 
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